😺 The ACTUAL ChatGPT 3 moment for robotics (one-shot learning)

So guess what: AI has now, OFFICIALLY, helped design a cancer treatment that just cleared Phase 3. Merck and Moderna reported the first positive Phase 3 result for an individualized mRNA cancer therapy, and the wild part is how each dose gets made.

Makes ya feel a LITTLE differently about all those datacenters now, doesn’t it? Here’s what’s up: Moderna says its AI algorithms take sequencing data from a patient’s tumor and blood, review the cancer’s mutations, and predict up to 34 “neoantigens” most likely to trigger.

What Happened

Those AI-selected targets are encoded into a custom mRNA therapy made for that patient, then paired with KEYTRUDA. In the melanoma trial, the combo significantly improved recurrence-free and distant-metastasis-free survival versus KEYTRUDA alone; overall-survival follow-up is still ongoing.

• Across 10 simple tasks, one demo produced 59% average success; 10 weight updates on five minutes of data raised that to 83%.

• Generalist says 10 steps changed GEN-1.5’s weights by less than 0.15%.

• The useful bit isn’t “use an agent.” It’s letting one job wake back up when the thing it is responsible for changes.

Key Details

This matters a lot to me personally, because my cousin died from Melanoma. Meanwhile, OpenAI is reportedly closing the door on new custom GPT creation for personal ChatGPT accounts, which got us wondering: how many people still build their AI workflows around.

• Ask a Cursor cloud agent to make the change and open a pull request.

• Cursor’s new Subscriptions let cloud agents monitor a pull request (a proposed code change) after they create it, wake back up when CI checks fail or a bot leaves feedback, and keep working without.

• If robots can make those new skills persist and compound without forgetting old ones, Sutton’s “learn from the current world” future starts looking a lot less abstract.

Why It Matters

Translation: are custom GPTs still part of your daily stack, or have they become the AI equivalent of an old Chrome extension you swear you still use? We've only got a few ad slots left in Q3 and they are going FAST!

• Generalist describes adaptation now as closer to reminding the model of something it nearly knows.

• It’s that eight months of broad physical pretraining made a few seconds of new experience useful.

What Reports Say

Coverage of the story so far points to:

• Continued reporting by The Neuron as more details emerge